![]() ![]() We used many references and there are too many to list here. The information on this page is based on literature searches and specialist checking. Volume 19, Issue 8: 2057-2070įood Bioactive Compounds and Their Interference in Drug Pharmacokinetic/Pharmacodynamic Profiles Volume 17, Issue 1: 521Ĭytochrome P450: Polymorphisms and Roles in Cancer, Diabetes and AtherosclerosisĪsian Pacific Journal of Cancer Prevention, 2018. ![]() Issue 134: 31-59Įffects of mistletoe products on pharmacokinetic drug turnover by inhibition and induction of cytochrome P450 activitiesīMC Complementary and Alternative Medicine, 2017. The mechanisms of pharmacokinetic food-drug interactions – A perspective from the UNGAP groupĮuropean Journao of Pharmaceutical Sciences, 2019. #Capsy cupso trialIf possible you might be able to join the trial if you can take another medication that doesn’t affect the CYP enzymes. Talk to your doctor or a member of the trial team if you are thinking of joining of a clinical trial. You might not be able to take part in clinical trials if you are taking a medication that affects the CYP enzymes. If this is the case your doctor might need to change the dose of your cancer drug. ![]() You might have another medical condition for which you are taking medication that might affect the CYP enzymes. They will also be able to advise you about any foods, medications or any supplements that might affect these enzymes. They will be able to tell you if they might affect the CYP enzymes. You must tell your doctor or pharmacist if you start a new medication or are thinking of taking some herbal supplements. There are many herbal supplements that affect the CYP enzymes. Herbal supplements that affect CYP enzymes There are many different types of drugs that can affect the CYP enzymes. Your doctor or pharmacist will tell you if you need to avoid particular foods or drink while on treatment. The food and drink you may need to avoid depend on the drug you are having and which CYP enzymes are involved. This includes their juice and other products that are mostly made from these, for example marmalade. The best known foods that affect the CYP enzymes are grapefruit and Seville oranges. ![]() Check with your doctor or pharmacist if you’re not sure. You may also read this in the drug information sheet enclosed with your medicine. So while you are taking certain drugs, your healthcare team may tell you to avoid some foods or herbal supplements. If too much of the cancer drug is broken down it might not work as well, and you might need a bigger dose which can possibly cause more side effects. If too little of the drug is broken down, you could have bad side effects from your cancer drug and you might need a smaller dose.įoods and other drugs, including herbal supplements, can affect the level of CYP enzymes in the body. This affects how well the drug works and the possible side effects. The amount of these enzymes in the body can affect how well the cancer drug is broken down. We know that certain ones affect how cancer drugs are broken down in the body. Most of these enzymes are made by the liver. CYP enzymesĪ group of enzymes called cytochrome P (CYP) are an important part of the process of how drugs are broken down in the body after they’ve been absorbed into the blood. This process happens in the gut (digestive system). Everything you take by mouth, including food, drink and medicine, needs to be absorbed by the body. ![]()
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